Senior Scientist II, ADC/AOC Conjugation

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

Job Description

Key Responsibilities

• Synthesis, purification, and characterization of antibody oligonucleotide conjugates (AOCs) and antibody drug conjugates (ADCs) on mg to gram scale under minimal supervision.
• Design and execute engineered cysteine antibody conjugation workflows
• Optimize reaction stoichiometry, linker chemistry, and reaction conditions to improve peptide-to-antibody ratios and product homogeneity.
• Development, optimization, and validation of conjugation protocols specifically for antibody oligonucleotide conjugates.
• Optimization and validation of formulation buffers for bioconjugates.
• Application and refinement of automated techniques for AOC/ADC synthesis and purification.
• Collaboration with cross-functional teams to advance AOC discovery programs from conceptualization to early development.
• Develop and optimize peptide–antibody conjugation strategies
• Optimize reaction stoichiometry, linker chemistry, and reaction conditions to improve peptide-to-antibody ratios and product homogeneity.
• Investigate and mitigate sources of conjugation heterogeneity such as over-reduction, disulfide scrambling, hydrolysis, and aggregation.
• Apply diverse conjugation chemistries including thiol-reactive linkers, maleimide coupling, NHS ester chemistry, and bioorthogonal click chemistry (e.g., azide–alkyne cycloaddition).
• Characterize conjugates using analytical techniques including SEC-HPLC, LC-MS (intact/reduced), RP-HPLC, and SDS-PAGE.
• Access external innovation to complement internal efforts

Qualifications

Qualifications

• Bachelor’s Degree or equivalent education and typically, 12 years of experience, Master’s Degree or equivalent education and typically 10 years of experience, PhD and typically 4 years of experience.​
• Expertise in the discovery, design, synthesis, and purification of Antibody Oligonucleotide Conjugates (AOC), including familiarity with associated chemistries and analytical methods.
• Hands-on experience with relevant analytical techniques such as HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis techniques (e.g., CE-SDS, icIEF).
• Proven problem-solving skills, motivation, enthusiasm, attention to detail, and the ability to thrive in a fast-paced, cross-disciplinary team environment.
• Superior written and oral communication skills, with a strong record of collaboration and innovation.
• Familiarity with biorthogonal conjugation techniques and next-generation site-specific conjugation platforms.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.

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