Senior Scientist II - Biologics Drug Product Development

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on X , Facebook , Instagram , YouTube , LinkedIn and Tik Tok .

Job Description

The Development Sciences Biologics Drug Product Development organization within AbbVie develops and characterizes drug product formulations and manufacturing processes to provide clinical dosage forms to enable the development of AbbVie’s pipeline. AbbVie is seeking a highly motivated person to join the Biologics CMC Developability Team. The candidate will leverage mass spectrometry and other advanced characterization techniques to support the early-stage assessment of candidates coming out of the Discovery pipeline with the opportunity to influence the design and development of stable drug product formulation and manufacturing processes for biologics used in clinical trials. In addition, the candidate will be expected to drive key scientific initiatives and lead innovative approaches to improve current workflows. In this role, the candidate will be a member of a global team and will work closely with scientists from multiple functional areas, including Discovery, Analytical, Process R&D, and Product Development Science & Technology.

Key Responsibilities:

• Lead developability assessment activities, including candidate screening and selection for clinical studies of monoclonal antibodies, antibody drug conjugates, bispecifics, and fusion proteins.
• Utilize analytical instruments to understand structural stability of biotherapeutic entities to influence candidate protein sequence design and selection.
• Develop independent research ideas and pursue scientific questions to continually improve developability approaches. Present data at internal and external professional conferences and prepare manuscripts for publication in peer reviewed journals or patent applications.
• Build and manage strategic alignments with key stakeholders, revise and improve business workflows, manage project timelines and resources. Develops the optimal CMC development path for assigned discovery projects together with clients from various R&D functions with an emphasis on collaboration, quality and with a sense of urgency.

Qualifications

Qualifications:

• Bachelor’s Degree or equivalent education and typically 12 years of experience OR Master’s Degree or equivalent education and typically 10 years of experience OR PhD and typically 4 years of experience.
• At least 2 years of industry experience in CMC Development of biotherapeutics are preferred
• Deep understanding of protein stability characterization (e.g., SEC, IEX, HIC, CE)
• Additional robotics expertise and digital data capture experience is beneficial
• Knowledge of functional excipient degradation pathways is a plus
• Solid understanding of the scientific approaches to develop commercially viable protein drug products

Key Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance.
• Excellent oral communication skills in a scientific setting as well as sound technical writing and documentation competencies are required.
• The candidate must be able to work independently, respond to changing priorities and short lead times for multiple tasks; able to identify problems and work toward solutions.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.

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