Research Scientist II -HCMG - RADC - Full-time

Location: Chicago, Illinois

Business Unit: Rush Medical Center

Hospital: Rush University Medical Center

Department: Rush Alzheimers Dis Ctr-ResFac

Work Type: Full Time (Total FTE between 0.9 and 1.0)

Shift: Shift 1

Work Schedule: 8 Hr (8:00:00 AM - 4:30:00 PM)

Rush offers exceptional rewards and benefits learn more at our Rush benefits page (

Pay Range: $32.00 - $52.08 per hour
Rush salaries are determined by many factors including, but not limited to, education, job-related experience and skills, as well as internal equity and industry specific market data. The pay range for each role reflects Rush’s anticipated wage or salary reasonably expected to be offered for the position. Offers may vary depending on the circumstances of each case.

Summary:
The Staff Research Scientist will design and perform complex scientific research experiments. This person will lead research efforts on human iPSC-based disease modeling or/and CRISPR gene perturbations. The job will perform experiments, analyze data, compile results, and monitor quality control processes to ensure integrity of research. The position will utilize knowledge of molecular biology, neurobiology, cell biology, human genomics, and stem cell biology. This person will troubleshoot and evaluate data, and prepare manuscripts based on experimental results. The work requires the application of highly specialized knowledge of brain development and human genetic/epigenetic regulations. Some of the related techniques that will be applied in the research to be conducted will include human iPSC cultures, neural differentiation, brain organoid cultures, high-content imaging, molecular biology, viral packaging, CRISPR gene perturbations and data analysis. Exemplifies the Rush mission, vision and values and acts in accordance with Rush policies and procedures.

Other information:
Required Job Qualifications:
• Ph.D. with 3 years expertise in Neuroscience, Cell biology, Developmental biology, Stem cell biology, molecular biology, or related field or a Master’s degree with 6 years of experience.
• Excellent skills and experience in human iPSC cultures, neural differentiation, and brain organoid cultures.
• Excellent skills and experience in assay development and high-content imaging.
• Excellent skills and experience in molecular biology and CRISPR gene perturbations
• Excellent project planning, organization, and problem-solving skills.
• Excellent communication and interpersonal skills
• Proven ability to work independently and in collaborative team environments.
• Ability to work for 8 hours daily in the lab.

Disclaimer: The above is intended to describe the general content of and requirements for the performance of this job. It is not to be construed as an exhaustive statement of duties, responsibilities, or requirements.

Responsibilities:
• Mentor technicians and graduate students
• Generate multi-cellular 2D and 3D culture models to incorporate different cell types
• Develop cellular, molecular, and functional assays to examine AD phenotype in the dish
• Conduct gene perturbation experiments to test AD candidate genes
• Collect and analyze multi-module data, including imaging, FACS, qRT-PCR, targeting sequencing etc.
• Coordinate other team members to successfully execute the research plan
• Prepare and/or publish scientific papers and manuscripts
• Contribute to grant writing
• Communicate with other RADC teams on related projects.
• Plan and conduct of statistical analysis of data
• Prepare abstracts and meeting materials to present (slides, posters) within scientific group
• Plan meetings (such as investigator meetings and other scientific/operational meetings)
• Design and execute complex research procedures.
• Develop and perform routine and complex protocols for research programs.
• Assist in developing, implementing, and monitoring quality activities.
• Collaborate with principal investigators in determining study design and performing statistical analyses.
• Perform and develop routine and complex computational and database methods for implementation.
• Participate in meetings with principal investigator and research staff and evaluate/interpret the validity of data, develop methodologies, evaluate lab procedures.
• May oversee the work of laboratory personnel including training and development as well as daily work direction/delegation/prioritizing.

Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.