Director, Translational Bioanalysis and Multi-Omics

Job Description

Job Description

The Allman Institute is a translational research organization applying personalized medicine to treat severe and historically difficult-to-treat diseases, beginning with pulmonary fibrosis and chronic lung transplant dysfunction. The Institute combines deep molecular profiling, longitudinal clinical data, and a pragmatic mix of mechanism-guided and large-scale empirical approaches to accelerate therapeutic discovery and translation.

We pursue an ambitious and pragmatic, modality-agnostic therapeutic strategy spanning genetic medicines, molecular and pharmacologic therapies, cell and immune-based interventions, and engineered biological systems, in close collaboration with leading academic and biotech partners across the U.S. and abroad. The Institute is established as a nonprofit, backed by substantial long-term capital committed directly to the mission. Where strategically valuable, we may pursue mission-aligned for-profit ventures, spin-outs, and partnerships to accelerate therapeutic development and patient impact.

We are a small but rapidly growing team of approximately 20, scaling to 40–50 over the next year across labs and offices in Redwood City, CA and Cambridge, MA, driven by scientific rigor, translational urgency, and a patient-anchored mandate.

We are seeking a Director of Translational Bioanalysis and Multi-Omics to lead efforts in measuring, analyzing, and interpreting molecular data from patient specimens and clinical studies. This role will be important in understanding disease biology, tracking therapeutic response, and identifying new drug targets in the context of rare lung diseases and small patient cohorts.

Responsibilities

Bioanalytical Strategy and Execution

• Develop and execute bioanalytical strategies for measuring patient specimens and clinical study samples in the context of n-of-1 and small-cohort rare disease efforts.

• Design and implement multi-omic analyses, including genomics, transcriptomics, proteomics, lipidomics, and related approaches, to understand disease mechanisms and therapeutic responses.

• Establish quantitative methods to measure biomarkers relevant to lung disease, fibrosis, epithelial function, and treatment effect.

• Determine which analytical methods and measurements best capture on-target drug activity and therapeutic efficacy over time.

Assay Development and Validation

• Develop, optimize, and validate bioanalytical assays for patient samples such as blood, bronchoalveolar lavage, tissue biopsies, and other relevant specimen types.

• Work with mass spectrometry-based methods, PCR and qPCR, sequencing-based approaches, and other analytical platforms as appropriate.

• Ensure assay methods meet standards for sensitivity, specificity, and reproducibility in the context of rare disease and translational research.

• Adapt existing assays or develop novel methods when standard approaches are insufficient.

Clinical Sample Management and Analysis

• Oversee sample collection, processing, storage, and tracking for clinical studies and patient cohorts.

• Coordinate logistics for specimen collection from multiple clinical sites while maintaining sample quality and integrity.

• Manage relationships with external CROs and specialized laboratories for assays requiring specific instrumentation or expertise.

• Build internal capability to run critical assays at the bench when external options are insufficient or turnaround time is important.

Data Integration and Target Identification

• Analyze multi-omic datasets to identify disease mechanisms, biomarkers, and potential therapeutic targets.

• Integrate molecular data with clinical phenotypes, imaging, pulmonary function tests, and other endpoints.

• Work with computational biology and AI teams to compare rare disease cohorts against larger external datasets and improve stratification and translational interpretation.

• Partner with scientific leadership to translate bioanalytical findings into actionable therapeutic hypotheses and pipeline opportunities.

Cross-Functional Collaboration

• Collaborate with clinical research, regulatory affairs, and CMC teams to ensure bioanalytical strategies support translational and clinical development goals.

• Work with external research partners to enable analysis of relevant existing datasets and cohorts.

• Communicate findings clearly to internal teams, advisors, and collaborators.

Team and Vendor Management

• Build and lead a team capable of executing complex bioanalytical studies from sample logistics through data analysis.

• Manage external CROs, core facilities, and specialized laboratory vendors.

• Create systems and processes that support rapid adaptation to changing study designs and priorities.

Qualifications

Required

• PhD in molecular biology, biochemistry, analytical chemistry, or a related field, or equivalent experience in bioanalytical sciences.

• 5–10 years of progressive experience in bioanalytical research, translational science, clinical investigation, or biotech/pharma bioanalysis.

• Deep expertise in multiple analytical platforms such as genomics, transcriptomics, proteomics, mass spectrometry, PCR/qPCR, or related technologies.

• Strong record of developing and validating bioanalytical assays for clinical or translational samples.

• Experience with clinical sample collection, processing, and management across studies or sites.

• Demonstrated ability to manage external vendors and CROs effectively.

• Strong data analysis skills and scientific judgment about which signals are relevant, measurable, and informative.

• Excellent organizational skills and ability to operate in dynamic environments requiring frequent adjustment.

Preferred

• Experience in rare disease research or small-cohort and n-of-1 studies.

• Background in lung disease, fibrosis, epithelial biology, or related translational research.

• Familiarity with biomarker strategies relevant to clinical development and IND-supporting work.

• Experience integrating multi-omic data with clinical endpoints.

• Track record of identifying biomarkers or drug targets that informed therapeutic development.

• Experience building and leading bioanalytical teams.

• Strong network across CROs, core facilities, and specialized laboratories.

Location and Work Environment

This position is expected to be based in the San Francisco Bay Area or Boston/Cambridge area, with flexibility for hybrid work arrangements. Regular on-site presence will be important for coordination with research teams and oversight of laboratory-facing work. Some travel to collaborator institutions, clinical sites, and vendor facilities may be required.

About the Role

This role is intended for a scientifically rigorous and operationally strong leader who can build a translational measurement capability from the ground up. The Director of Translational Bioanalysis and Multi-Omics will help connect patient specimens, clinical data, and molecular signals to decisions about programs, targets, and therapeutic strategy.